Un-‘Egg’-Plored: Characterisation of Embryonation in the Whipworm Model Organism Trichuris muris
نویسندگان
چکیده
Trichuris muris , is the murine parasite and widely deployed model for human whipworm trichiura a that infects around 500 million people globally. Trichuriasis classical disease of poverty with cycle re-infection due to continual exposure humans, particularly children, infective eggs, which contaminate soil in endemic areas. Indeed, modelling studies trichuriasis have demonstrated low efficacy rate current anthelmintics combined high possibility from reservoir eggs within environment, mean elimination morbidity unlikely occur. Despite importance egg stage perpetuation infections, understanding biology ova has been neglected decades. Here we perform experiments assess impact temperature on embryonation process T. describe detail stages larval development these eggs. In keeping early works performed 1900s, show accelerated by an elevation temperature, up 37°C above do not fully develop become degenerate. We extend data provide detailed description clear images depicting various development. To best our knowledge have, first time, described presence birefringent granules egg-stage larvae, as well providing qualitative quantitative motile prior quiescence egg. These are step towards better basic underlies embryonation. With threat global temperatures, observe at higher temperatures may important consequences transmission rates prospective studies. addition, deeper allow novel control strategies targeting environment adjunct MDA.
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ژورنال
عنوان ژورنال: Frontiers in tropical diseases
سال: 2021
ISSN: ['2673-7515']
DOI: https://doi.org/10.3389/fitd.2021.790311